Annotation Detail
Information
- Associated Genes
- AIFM1
- Associated Variants
- AIFM1 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- Sorafenib (BRAF, CRAF, VEGFR and PDGFR inhibitor) is active against melanoma cells in which AIF mediates apoptosis (is independent of Bad phosphorylation status)
- MMMP State
- downregulated by
- MMMP Molecule
- AIF
- MMMP Molecule Alias
- Apoptosis inducing factor
- MMMP Modifier
- AIF siRNA
- MMMP Relationship
- resistance to
- MMMP Drug
- Sorafenib
- MMMP Drug Alias
- Nexavar (R)
- MMMP Model
- 3
- MMMP Reference
- Panka DJ, Cancer Res 2006, 66:1611-9
- MMMP DNA/mRNA/Protein
- mRNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Sorafenib | Resitance or Non-Reponse | true |