Annotation Detail
Information
- Associated Genes
- RPS6KA1
- Associated Variants
- RPS6KA1 UNKNOWN
- Source Database
- MMMP
- Description
- PD98059 is a MEK1 inhibitor. MEK phosphorylates and activates ERK, which phosphorylates and activates RSK (which phosphorylates and inhibits Bad)
- MMMP State
- phosphorylated (activated)
- MMMP Molecule
- RSK1
- MMMP Molecule Alias
- Ribosomal S6 kinase (RS6K)
- MMMP Relationship
- resistance to
- MMMP Drug
- PD98059
- MMMP Drug Alias
- MEK inhibitor
- MMMP Model
- 3
- MMMP Reference
- Eisenmann KM, Cancer Res 2003, 63:8330-7
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| PD98059 | Resitance or Non-Reponse | true |