Annotation Detail
Information
- Associated Genes
- TP53
- Associated Variants
- TP53 WILD_TYPE
- Source Database
- MMMP
- Description
- DW1/2 is a GSK3 beta inhibitor that activates wild type p53 (not mutated p53) by decreasing HDM2 (MDM2) levels
- MMMP State
- wild type (vs mutated)
- MMMP Molecule
- p53
- MMMP Molecule Alias
- TP53
- MMMP Relationship
- sensitivity to
- MMMP Drug
- DW1/2
- MMMP Model
- 3
- MMMP Reference
- Smalley KS, Cancer Res 2007, 67:209-17
- MMMP DNA/mRNA/Protein
- DNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| DW1/2 | Sensitivity | true |