Annotation Detail
Information
- Associated Genes
- BRAF
- Associated Variants
- BRAF V600E
- Source Database
- MMMP
- Description
- Oncogenic BRAF causes chemoresistance by promoting ERK-dependent inactivation of Bad and Bim, which in turn causes apoptosis inhibition
- MMMP State
- mut V600E
- MMMP Molecule
- BRAF
- MMMP Molecule Alias
- B-Raf
- MMMP Relationship
- resistance to
- MMMP Drug
- Actinomycin-D
- MMMP Model
- 3
- MMMP Reference
- Sheridan C, J Biol Chem 2008, 283:22128-35
- MMMP DNA/mRNA/Protein
- DNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Actinomycin-D | Resitance or Non-Reponse | true |