Annotation Detail
Information
- Associated Genes
- KIT
- Associated Variants
- KIT D820Y
- Source Database
- MMMP
- Description
- Acral lentiginous melanoma. Sunitinib is a small molecule inhibitor of various receptor tyrosine kinases such as VEGFR, PDGFR, KIT, RET. A significant growth suppressive effect of sunitinib was observed in an acral melanoma cell line harboring the D820Y mutation
- MMMP State
- mut D820Y
- MMMP Molecule
- KIT
- MMMP Molecule Alias
- c-KIT
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Sunitinib
- MMMP Drug Alias
- Sutent (R)
- MMMP Model
- 3
- MMMP Reference
- Ashida A, Int J Cancer 2009, 124:862-8
- MMMP DNA/mRNA/Protein
- DNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Sunitinib | Sensitivity | true |