Annotation Detail
Information
- Associated Genes
- ABCB8
- Associated Variants
- ABCB8 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- ABCB8 mediates the resistance to doxorubicin (but not other drugs) in melanoma cells, likely by protecting the mitochondrial genome
- MMMP State
- downregulated by
- MMMP Molecule
- ABCB8
- MMMP Modifier
- ABCB8 siRNA
- MMMP Relationship
- no relationship with
- MMMP Drug
- 5-Fluorouracil
- MMMP Drug Alias
- 5-FU
- MMMP Model
- 3
- MMMP Reference
- Elliott AM, Mol Cancer Res 2009, 7:79-87
- MMMP DNA/mRNA/Protein
- mRNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| 5-Fluorouracil | Resitance or Non-Reponse | true |