Annotation Detail
Information
- Associated Genes
- XBP1
- Associated Variants
- XBP1 EXPRESSION
- Source Database
- MMMP
- Description
- XBP-1 (an ER stress response protein) activates AKT. These results identify activation of the PI3K/Akt pathway by XBP-1-mediated signaling of the unfolded protein response as a resistance mechanism against docetaxel and vincristine in melanoma cells under ER stress
- MMMP State
- expressed
- MMMP Molecule
- XBP-1
- MMMP Relationship
- resistance to
- MMMP Drug
- Vincristine
- MMMP Model
- 3
- MMMP Reference
- Jiang CC, Neoplasia 2009, 11:436-47
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Vincristine | Resitance or Non-Reponse | true |