Annotation Detail
Information
- Associated Genes
- TEK
- Associated Variants
- TEK UNDEREXPRESSION
- Source Database
- MMMP
- Description
- Soluble Tie2 inhibits the Tie2 pathway (Tie2 is the receptor for angiopoietin-1). Tie2Ex failed to inhibit the growth of established K1735 tumors. These tumors were additionally treated with sorafenib, a multikinase inhibitor that inhibits tumor endothelial cell ERK activation but not AKT activation. Combining Tie2Ex and sorafenib decreased both endothelial cell AKT and ERK activation, decreased endothelial cell survival and proliferation, and significantly inhibited growth of established tumors
- MMMP State
- inhibited by
- MMMP Molecule
- Tie2
- MMMP Molecule Alias
- TEK
- MMMP Modifier
- Soluble Tie2
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Sorafenib
- MMMP Drug Alias
- Nexavar (R)
- MMMP Model
- 2
- MMMP Reference
- Tsai JH, Mol Cancer Res 2009, 7:300-10
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Sorafenib | Sensitivity | true |