Annotation Detail
Information
- Associated Genes
- MAP2K1
- Associated Variants
- MAP2K1 P124L
- Source Database
- MMMP
- Description
- AZD6244 is a MEK inhibitor. The mutation found in a drug resistant human melanoma was demonstrated to be responsible for drug resistance in an in vitro human model
- MMMP State
- mut P124L
- MMMP Molecule
- MEK1
- MMMP Relationship
- resistance to
- MMMP Drug
- AZD6244
- MMMP Model
- 5
- MMMP Reference
- Emery CM, Proc Natl Acad Sci USA 2009, 106:20411-6
- MMMP DNA/mRNA/Protein
- DNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| AZD6244 | Resitance or Non-Reponse | true |