Annotation Detail

Information
Associated Genes
TLR3
Associated Variants
TLR3 OVEREXPRESSION
Source Database
MMMP
Description
LBW242 is a SMAC mimetic and thus a IAP inhibitor. Sensitisation towards poly I:C-dependent caspase-8 activation and apoptosis in melanoma cells was also achieved by the synthetic Smac mimetic/inhibitor of apoptosis protein (IAP) antagonist, LBW242, or by specific downregulation of cIAP1 by siRNA
MMMP State
activated by
MMMP Molecule
TLR3
MMMP Molecule Alias
Toll like receptor 3
MMMP Modifier
Poly (I:C)
MMMP Modifier Alias
Poly(inosine:cytosine)
MMMP Relationship
sensitivity to
MMMP Drug
LBW242
MMMP Drug Alias
Smac mimetic
MMMP Model
3
MMMP Reference
Weber A, Cell Death Differ 2010, 17:942-51
MMMP DNA/mRNA/Protein
protein
Drugs
Drug NameSensitivitySupported
LBW242Sensitivitytrue