Annotation Detail
Information
- Associated Genes
- IFNAR1
- Associated Variants
- IFNAR1 OVEREXPRESSION
- Source Database
- MMMP
- Description
- IFN-alpha enhances peptide vaccine-induced CD8+ T cell numbers, effector function, and antitumor activity. These results demonstrate the efficacy of IFN-alpha as an adjuvant for peptide vaccination, give insight into its mechanism of action, and provide a rationale for clinical trials in which vaccination is combined with standard-of-care IFN-alpha therapy for melanoma
- MMMP State
- activated by
- MMMP Molecule
- IFNAR
- MMMP Modifier
- IFN alpha
- MMMP Modifier Alias
- Interferon alpha
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Vaccine (gp100 peptide)
- MMMP Model
- 2
- MMMP Reference
- Sikora AG, J Immunol 2009, 182:7398-407
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Vaccine (gp100 peptide) | Sensitivity | true |