Annotation Detail
Information
- Associated Genes
- HDAC9
- Associated Variants
- HDAC9 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- In a phase I-II trial of valproic acid (histone deacetylase [HDAC] inhibitor) plus chemoimmunotherapy (DTIC + IFN-alpha), this combination regimen did not produce results overtly superior to standard therapy in patients with advanced melanoma
- MMMP State
- inhibited by
- MMMP Molecule
- HDAC
- MMMP Molecule Alias
- Histone deacetylase
- MMMP Modifier
- Valproic acid
- MMMP Relationship
- no relationship with
- MMMP Drug
- Dacarbazine + IFN alpha
- MMMP Model
- 5
- MMMP Reference
- Rocca A, Br J Cancer 2009, 100:28-36
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Dacarbazine + IFN alpha | Resitance or Non-Reponse | true |