Annotation Detail
Information
- Associated Genes
- PTGS2
- Associated Variants
- PTGS2 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- In this phase II RCT (advanced melanoma), combination therapy was associated with significantly improved progression free survival. Note: rofecoxib has been withdrawn from the market due to cardiovascular toxicity
- MMMP State
- inhibited by, activated by
- MMMP Molecule
- COX-2, PPAR gamma
- MMMP Modifier
- Rofecoxib + Pioglitazone
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Trofosfamide
- MMMP Model
- 6
- MMMP Reference
- Reichle A, Melanoma Res 2007, 17:360-4
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Trofosfamide | Sensitivity | true |