Annotation Detail
Information
- Associated Genes
- IL2RA
- Associated Variants
- IL2RA OVEREXPRESSION
- Source Database
- MMMP
- Description
- In this phase I-II trial, there is no evidence to support a synergistic effect of CTLA-4 blockade plus IL-2 administration, because the 22% objective response rate is that expected from the sum of these two agents administered alone
- MMMP State
- activated by
- MMMP Molecule
- IL2R
- MMMP Molecule Alias
- Interleukin-2 receptor
- MMMP Modifier
- IL-2
- MMMP Modifier Alias
- Interleukin-2
- MMMP Relationship
- no relationship with
- MMMP Drug
- CTLA4 antibody (antagonist)
- MMMP Model
- 5
- MMMP Reference
- Maker AV, Ann Surg Oncol 2005, 12:1005-16
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| CTLA4 antibody (antagonist) | Resitance or Non-Reponse | true |