Annotation Detail
Information
- Associated Genes
- CTLA4
- Associated Variants
- CTLA4 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- In this phase I-II trial, there is no evidence to support a synergistic effect of CTLA-4 blockade plus IL-2 administration, because the 22% objective response rate is that expected from the sum of these two agents administered alone
- MMMP State
- inhibited by
- MMMP Molecule
- CTLA4
- MMMP Modifier
- CTLA4 antibody (antagonist)
- MMMP Relationship
- no relationship with
- MMMP Drug
- IL-2
- MMMP Drug Alias
- Interleukin-2
- MMMP Model
- 5
- MMMP Reference
- Maker AV, Ann Surg Oncol 2005, 12:1005-16
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| IL-2 | Resitance or Non-Reponse | true |