Annotation Detail
Information
- Associated Genes
- IFNAR1
- Associated Variants
- IFNAR1 OVEREXPRESSION
- Source Database
- MMMP
- Description
- Despite stabilizing IFNAR, Sorafenib - while inhibiting melanoma cell growth by itself - attenuated the anti-proliferative effects of IFN alpha, likely by inhibiting the IFN signaling in 1205Lu human melanoma cells (e.g., inhibits JAK activity)
- MMMP State
- activated by
- MMMP Molecule
- IFNAR
- MMMP Molecule Alias
- IFN alpha receptor
- MMMP Modifier
- IFN alpha
- MMMP Modifier Alias
- Interferon alpha
- MMMP Relationship
- resistance to
- MMMP Drug
- Sorafenib
- MMMP Drug Alias
- Nexavar (R)
- MMMP Model
- 3
- MMMP Reference
- Kumar KG, Cancer Biol Ther 2007, 6:1437-41
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Sorafenib | Resitance or Non-Reponse | true |