Annotation Detail
Information
- Associated Genes
- TYRO3
- Associated Variants
- TYRO3 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- The receptor protein tyrosine kinase TYRO3 is an upstream regulator of MITF expression (TYRO3 induces MITF-M expression in a SOX10-dependent manner in melanoma cells). Its knockdown shows synergistic activity with docetaxel
- MMMP State
- downregulated by
- MMMP Molecule
- TYRO3
- MMMP Molecule Alias
- Sky, TYRO3 protein tyrosine kinase
- MMMP Modifier
- TYRO3 siRNA
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Docetaxel
- MMMP Model
- 3
- MMMP Reference
- Zhu S, Proc Natl Acad Sci USA 2009, 106:17025-30
- MMMP DNA/mRNA/Protein
- mRNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Docetaxel | Sensitivity | true |