Annotation Detail
Information
- Associated Genes
- PTGS2
- Associated Variants
- PTGS2 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- In this phase II trial (metastatic setting), low-dose, continuous intravenous infusion paclitaxel and oral celecoxib produced one partial response (5%) and three (15%) disease stabilizations in heavily pretreated patients with melanoma
- MMMP State
- downregulated by
- MMMP Molecule
- COX-2
- MMMP Molecule Alias
- Cyclooxygenase 2
- MMMP Modifier
- Celecoxib
- MMMP Relationship
- no relationship with
- MMMP Drug
- Paclitaxel (metronomic schedule)
- MMMP Drug Alias
- Taxol
- MMMP Model
- 5
- MMMP Reference
- Bhatt RS, Cancer 2010, 116:1751-6
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Paclitaxel (metronomic schedule) | Resitance or Non-Reponse | true |