Annotation Detail
Information
- Associated Genes
- MAPK8
- Associated Variants
- MAPK8 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- Celastrol and AIGA have anti-melanoma effects likely by acting as ATF2 inhibitors, which seems to require JNK activity
- MMMP State
- inhibited by
- MMMP Molecule
- JNK
- MMMP Modifier
- SP600125
- MMMP Modifier Alias
- JNK inhibitor
- MMMP Relationship
- resistance to
- MMMP Drug
- Celastrol
- MMMP Model
- 1
- MMMP Reference
- Abbas S, Clin Cancer Res 2007, 13(22 Pt 1):6769-78
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Celastrol | Resitance or Non-Reponse | true |