Annotation Detail
Information
- Associated Genes
- MAP2K7
- Associated Variants
- MAP2K7 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- TW-37 inhibits Bcl-2, Bcl-xL and Mcl-1. This combination regimen is tumor selective through ROS/p53 activation (which does not occur in normal melanocytes)
- MMMP State
- inhibited by
- MMMP Molecule
- MEK
- MMMP Modifier
- U0126
- MMMP Relationship
- sensitivity to
- MMMP Drug
- TW-37
- MMMP Model
- 4
- MMMP Reference
- Verhaegen M, Cancer Res 2006, 66:11348-59
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| TW-37 | Sensitivity | true |