Annotation Detail
Information
- Associated Genes
- PARP1
- Associated Variants
- PARP1 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- Compounds 24 and 44, featuring an oxadiazole and a pyridine moiety, respectively, demonstrated balanced potency and pharmacokinetics profiles: these two molecules exhibited potent oral in vivo efficacy in potentiating the cytotoxic agent temozolomide in a B16F10 murine melanoma model
- MMMP State
- inhibited by
- MMMP Molecule
- PARP-1
- MMMP Molecule Alias
- Poly ADP-ribose polymerase 1
- MMMP Modifier
- PARP-1 inhibitors (benzimidazole-based)
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Temozolomide
- MMMP Drug Alias
- TMZ
- MMMP Model
- 2
- MMMP Reference
- Tong Y, J Med Chem 2009, 52:6803-13
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Temozolomide | Sensitivity | true |