Annotation Detail
Information
- Associated Genes
- MAP2K7
- Associated Variants
- MAP2K7 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- LY294002 is a PI3K inhibitor. Both MEK and PI3K/AKT must be inhibited to restore BAD pro-apoptotic activity. The cell line used is PTEN deficient
- MMMP State
- inhibited by
- MMMP Molecule
- MEK
- MMMP Modifier
- CI-1040
- MMMP Relationship
- sensitivity to
- MMMP Drug
- LY294002
- MMMP Drug Alias
- AKT inhibitor
- MMMP Model
- 3
- MMMP Reference
- She QB, Cancer Cell 2005, 8:287-97
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| LY294002 | Sensitivity | true |