Annotation Detail
Information
- Associated Genes
- CTLA4
- Associated Variants
- CTLA4 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- The combination of MART-1 peptide-pulsed DC and tremelimumab results in objective and durable tumor responses (4/16) at the higher range of the expected response rate with either agent alone. No direct demonstration of synergism (phase I-II trial)
- MMMP State
- inhibited by
- MMMP Molecule
- CTLA4
- MMMP Modifier
- Tremelimumab
- MMMP Modifier Alias
- CTLA4 antibody (antagonist)
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Vaccine (dendritic cells)
- MMMP Model
- 5
- MMMP Reference
- Ribas A, Clin Cancer Res 2009, 15:6267-76
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Vaccine (dendritic cells) | Sensitivity | true |