Annotation Detail
Information
- Associated Genes
- HDAC9
- Associated Variants
- HDAC9 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- In melanoma cells with high MAGE-A expression, trichostatin synergizes with etoposide. MAGE-A acts through p53 inhibition in p53 wild type melanoma cells (the MAGE/p53 complex recruits HDAC3, which downregulates the transactivation function of p53)
- MMMP State
- inhibited by
- MMMP Molecule
- HDAC
- MMMP Molecule Alias
- Histone deacetylase
- MMMP Modifier
- Trichostatin
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Etoposide
- MMMP Drug Alias
- VP-16
- MMMP Model
- 3
- MMMP Reference
- Monte M, Proc Natl Acad Sci USA 2006, 103:11160-5
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Etoposide | Sensitivity | true |