Annotation Detail
Information
- Associated Genes
- MAP2K7
- Associated Variants
- MAP2K7 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- ERK1/2 (which is activated by MEK1/2) is highly phosphorylated in melanoma metastases and protects melanoma cells from cisplatin-mediated apoptosis likely by activating RSK1, which inactivates BAD
- MMMP State
- inhibited by
- MMMP Molecule
- MEK
- MMMP Modifier
- U0126
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Cisplatin
- MMMP Drug Alias
- CDDP
- MMMP Model
- 3
- MMMP Reference
- Mirmohammadsadegh A, J Invest Dermatol 2007, 127:2207-15
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Cisplatin | Sensitivity | true |