Annotation Detail
Information
- Associated Genes
- TP53
- Associated Variants
- TP53 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- It is unclear why inhibition of p53 with PFT-alpha resulted in an increase in apoptosis of human melanoma cells (particularly because apoptosis of TK6 lymphoma cells was inhibited)
- MMMP Model
- 3
- MMMP State
- inhibited by
- MMMP Molecule
- p53
- MMMP Molecule Alias
- TP53
- MMMP Modifier
- Pifithrin alpha
- MMMP Modifier Alias
- QB102 (PFT-alpha)
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Temozolomide
- MMMP Drug Alias
- TMZ
- MMMP Reference
- Mhaidat NM, Br J Cancer 2007, 97:1225-33
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Temozolomide | Sensitivity | true |