Annotation Detail
Information
- Associated Genes
- CDK4
- Associated Variants
- CDK4 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- PD98059: MEK inhibitor. Investigators examined the effect of cotargeting both pathways with MEK inhibitor PD98059 and CDK4 inhibitor 219476 on human melanoma cells lines, and found that combinatorial treatment dramatically increased apoptosis compared to the single agent treatment
- MMMP State
- inhibited by
- MMMP Molecule
- CDK4
- MMMP Molecule Alias
- Cyclin dependent kinase-4
- MMMP Modifier
- 219476
- MMMP Modifier Alias
- CDK4 inhibitor
- MMMP Relationship
- sensitivity to
- MMMP Drug
- PD98059
- MMMP Drug Alias
- MEK inhibitor
- MMMP Model
- 3
- MMMP Reference
- Li J, Cancer Invest 2009, Epub ahead of print
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| PD98059 | Sensitivity | true |