Annotation Detail
Information
- Associated Genes
- MAP2K1
- Associated Variants
- MAP2K1 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- Pretreatment of 1205Lu cells with MEK1 inhibitor PD098059 noticeably enhanced the anti-proliferative effects of IFN alpha. This is likely due to reduced activity of bTrCP, which in turn leads to increased IFNAR stability
- MMMP State
- inhibited by
- MMMP Molecule
- MEK1
- MMMP Modifier
- PD098059
- MMMP Relationship
- sensitivity to
- MMMP Drug
- IFN alpha
- MMMP Model
- 3
- MMMP Reference
- Kumar KG, Cancer Biol Ther 2007, 6:1437-41
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| IFN alpha | Sensitivity | true |