Annotation Detail
Information
- Associated Genes
- MAP2K7
- Associated Variants
- MAP2K7 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- Inhibition of MEK sensitizes human melanoma cells to endoplasmic reticulum stress-induced apoptosis. Also MEK1 siRNA increases ER stress mediated apoptosis caused by thapsigargin
- MMMP State
- inhibited by
- MMMP Molecule
- MEK
- MMMP Modifier
- U0126
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Thapsigargin
- MMMP Model
- 3
- MMMP Reference
- Jiang CC, Cancer Res 2007, 67:9750-61
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Thapsigargin | Sensitivity | true |