Annotation Detail
Information
- Associated Genes
- MAP2K7
- Associated Variants
- MAP2K7 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- Akti4 is an AKT inhibitor. Suppression of the MAP kinase and PI3K/Akt pathways showed potent anti-melanoma cell effects, including the inhibition of cell proliferation, transformation and invasion, induction of G(0)/G(1) cell cycle arrest and, when the two pathways were dually suppressed, cell apoptosis
- MMMP State
- inhibited by
- MMMP Molecule
- MEK
- MMMP Modifier
- U0126
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Akti4
- MMMP Model
- 3
- MMMP Reference
- Hou P, PLoS One 2009, 4:e6200
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Akti4 | Sensitivity | true |