Annotation Detail
Information
- Associated Genes
- CTLA4
- Associated Variants
- CTLA4 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- In a phase II trial (n=72), anti-CTLA4 antibody ipilimumab + DTIC yielded a 14.3% tumor response rate in patients with advanced melanoma (ipilimumab alone: 5.4%)
- MMMP State
- inhibited by
- MMMP Molecule
- CTLA4
- MMMP Modifier
- Ipilimumab
- MMMP Modifier Alias
- CTLA4 antibody (antagonist)
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Dacarbazine
- MMMP Drug Alias
- DTIC
- MMMP Model
- 5
- MMMP Reference
- Hersh EM, Invest New Drugs 2010, Epub ahead of print
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Dacarbazine | Sensitivity | true |