Annotation Detail
Information
- Associated Genes
- MAP2K7
- Associated Variants
- MAP2K7 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- AZD6244 treatment decreased phospho-ERK in the tumors and significantly suppressed tumor growth. The original tumors remained viable, suggesting that AZD6244 monotherapy was largely cytostatic, and not proapoptotic in this model. Further studies showed that co-administration of AZD6244 (30 mg/kg) with docetaxel (15 mg/kg) led to tumor regression
- MMMP State
- inhibited by
- MMMP Molecule
- MEK
- MMMP Modifier
- AZD6244
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Docetaxel
- MMMP Model
- 4
- MMMP Reference
- Haass NK, Clin Cancer Res 2008, 14:230-9
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Docetaxel | Sensitivity | true |