Annotation Detail
Information
- Associated Genes
- SRC
- Associated Variants
- SRC UNDEREXPRESSION
- Source Database
- MMMP
- Description
- Dasatinib in combination with the chemotherapy drug temozolomide showed greater efficacy than either drug alone. Dasatinib inhibition of proliferation was associated with reduced phosphorylation of Src kinase, while decreased phosphorylation of FAK was implicated in dasatinib-mediated inhibition of migration and invasion in melanoma cells
- MMMP State
- inhibited by
- MMMP Molecule
- SRC
- MMMP Molecule Alias
- c-Src
- MMMP Modifier
- Dasatinib
- MMMP Modifier Alias
- BMS-354825, Sprycel
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Temozolomide
- MMMP Drug Alias
- TMZ
- MMMP Model
- 3
- MMMP Reference
- Eustace AJ, J Transl Med 2008, 6:53
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Temozolomide | Sensitivity | true |