Annotation Detail
Information
- Associated Genes
- MAP2K1
- Associated Variants
- MAP2K1 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- SB239063: p38MAPK inhibitor. Unlike carcinoma cells, in melanoma cells MAPK-ERK and MAPK-p38 activity is not mutually exclusive and instead synergically increases melanoma migration and proliferation
- MMMP Drug
- SB239063
- MMMP Model
- 4
- MMMP State
- inhibited by
- MMMP Molecule
- MEK1
- MMMP Modifier
- PD98059
- MMMP Modifier Alias
- MEK inhibitor
- MMMP Relationship
- sensitivity to
- MMMP Reference
- Estrada Y, Pigment Cell Melanoma Res 2009, 22:66-76
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| SB239063 | Sensitivity | true |