Annotation Detail
Information
- Associated Genes
- MAP2K7
- Associated Variants
- MAP2K7 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- Rapamycin is a mTOR inhibitor. Combined treatment with rapamycin and PD325901 led to shrinkage of established melanomas. Model: murine melanoma spontaneously developed following conditional melanocyte-specific expression of BRAF V600E and PTEN loss
- MMMP State
- inhibited by
- MMMP Molecule
- MEK
- MMMP Modifier
- PD325901
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Rapamycin
- MMMP Drug Alias
- Sirolimus
- MMMP Model
- 2
- MMMP Reference
- Dankort D, Nat Genet 2009, 41:544-52
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Rapamycin | Sensitivity | true |