Annotation Detail
Information
- Associated Genes
- ABCB1
- Associated Variants
- ABCB1 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- The ATF2 peptide spanning amino acids 50-100 - which acts as an AFT2 inhibitor - elicited the most efficient increase in the sensitivity of human melanoma cells to UV radiation or treatment by Adriamycin, verapamil or UCN-01, as revealed by apoptosis assays
- MMMP State
- inhibited by
- MMMP Molecule
- ABCB1
- MMMP Molecule Alias
- MDR1, P-gp
- MMMP Modifier
- Verapamil
- MMMP Relationship
- sensitivity to
- MMMP Drug
- ATF2 peptide (antagonist)
- MMMP Model
- 3
- MMMP Reference
- Bhoumik A, Clin Cancer Res 2001, 7:331-42
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| ATF2 peptide (antagonist) | Sensitivity | true |