Annotation Detail
Information
- Associated Genes
- MAPK8
- Associated Variants
- MAPK8 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- Pretreatment of melanoma cells with the JNK inhibitor (SP600125) or the p38 inhibitor (SB203580) blocked taxol-induced UCP2 downregulation, ROS generation and apoptosis, whereas the ERK inhibitor (PD98059) had no such effect.
- MMMP State
- inhibited by
- MMMP Molecule
- JNK
- MMMP Modifier
- SP600125
- MMMP Modifier Alias
- JNK inhibitor
- MMMP Relationship
- resistance to
- MMMP Drug
- Paclitaxel
- MMMP Drug Alias
- Taxol
- MMMP Model
- 3
- MMMP Reference
- Selimovic D, Cell Signal 2008, 20:311-22
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Paclitaxel | Resitance or Non-Reponse | true |