Annotation Detail
Information
- Associated Genes
- CD226
- Associated Variants
- CD226 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- DNAM-1 (as well as natural cytotoxicity receptors, NCR) mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo
- MMMP State
- inhibited by
- MMMP Molecule
- DNAM1
- MMMP Molecule Alias
- CD226
- MMMP Modifier
- DNAM1 antibody (antagonist)
- MMMP Relationship
- resistance to
- MMMP Drug
- NK cell lysis (immunotherapy)
- MMMP Model
- 4
- MMMP Reference
- Lakshmikanth T, J Clin Invest 2009, 119:1251-63
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| NK cell lysis (immunotherapy) | Resitance or Non-Reponse | true |