Annotation Detail
Information
- Associated Genes
- NQO1
- Associated Variants
- NQO1 EXPRESSION
- Source Database
- MMMP
- Description
- DCPIP (redox dye 2,6-dichlorophenolindophenol) apoptogenicity observed in the human melanoma cell lines A375 and G361 was inversely correlated with NAD(P)H:quinone oxidoreductase (NQO1) expression levels. NQO1 inhibition by siRNA restores sensitivity to DCPIP. Systemic administration of DCPIP displayed significant antimelanoma activity in the A375 murine xenograft model. These findings suggest feasibility of targeting tumors that display low NQO1 enzymatic activity using DCPIP
- MMMP Model
- 4
- MMMP State
- expressed
- MMMP Molecule
- NQO1
- MMMP Molecule Alias
- NADPH quinone oxidoreductase
- MMMP Relationship
- resistance to
- MMMP Drug
- DCPIP
- MMMP Drug Alias
- MMMP Reference
- Cabello CM, Biochem Pharmacol 2009, 78:344-54
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| DCPIP | Resitance or Non-Reponse | true |