Annotation Detail

Information
Associated Genes
MC1R
Associated Variants
MC1R UNKNOWN
Source Database
MMMP
Description
Treatment with the cAMP-inducing compounds alpha-MSH (alpha-melanocyte stimulating hormone) and IBMX (3-isobutyl-1-methylxanthine) significantly suppressed the in vitro invasiveness and anchorage-independent growth in a semi-solid agar of melanoma cells. In animal experiments, the metastatic potential of the alpha-MSH- or IBMX-treated B16F10 melanoma cells was decreased compared to untreated control cells
MMMP State
uncharacterized
MMMP Molecule
MC1R
MMMP Molecule Alias
Melanocortin receptor 1
MMMP Relationship
sensitivity to
MMMP Drug
MSH
MMMP Drug Alias
Melanocyte stimulating hormone
MMMP Model
2
MMMP Reference
Kim A, Exp Cell Res 2009, 315:3325-35
Drugs
Drug NameSensitivitySupported
MSHSensitivitytrue