Annotation Detail
Information
- Associated Genes
- GOLPH3
- Associated Variants
- GOLPH3 EXPRESSION
- Source Database
- MMMP
- Description
- Using siRNA technology, these authors show that GOLPH3-expressing tumors are significantly more sensitive to rapamycin in vivo.Since GOLPH3 acts as an oncogene, they conclude that GOLPH3’s biochemical effect on mTOR signaling is a critical aspect of its oncogenic function, as inhibition by rapamycin effectively blocked the growth advantage conferred by GOLPH3 in vivo
- MMMP State
- expressed
- MMMP Molecule
- GOLPH3
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Rapamycin
- MMMP Drug Alias
- Sirolimus
- MMMP Model
- 4
- MMMP Reference
- Scott KL, Nature 2009, 459:1085-90
- MMMP DNA/mRNA/Protein
- mRNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Rapamycin | Sensitivity | true |