Annotation Detail
Information
- Associated Genes
- EGFR
- Associated Variants
- EGFR UNDEREXPRESSION
- Source Database
- MMMP
- Description
- To characterize tumor cell-independent stromal effects of EGFR targeting, mice were injected with B16 melanoma cells not expressing significant quantities of EGFR. The EGFR inhibitor gefitinib suppresses recruitment of pericytes and bone marrow-derived perivascular cells into tumor vessels
- MMMP State
- downregulated
- MMMP Molecule
- EGFR
- MMMP Molecule Alias
- ERBB1
- MMMP Relationship
- no relationship with
- MMMP Drug
- Gefitinib
- MMMP Drug Alias
- ZD1839 (Iressa (R))
- MMMP Model
- 2
- MMMP Reference
- Iivanainen E, Microvasc Res 2009, 78:278-85
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Gefitinib | Resitance or Non-Reponse | true |