Annotation Detail
Information
- Associated Genes
- REV3L
- Associated Variants
- REV3L UNDEREXPRESSION
- Source Database
- MMMP
- Description
- These data show that Rev3L contributes to temozolomide and fotemustine resistance, thus acting in concert with O6-methylguanine-DNA methyltransferase, BER, mismatch repair, and double-strand break repair in defense against simple alkylating anticancer drugs
- MMMP State
- downregulated by
- MMMP Molecule
- REV3L
- MMMP Molecule Alias
- Catalytic subunit of DNA polymerase zeta
- MMMP Modifier
- REV3L knockout
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Fotemustine
- MMMP Model
- 1
- MMMP Reference
- Roos WP, Mol Pharmacol 2009, 76:927-34
- MMMP DNA/mRNA/Protein
- mRNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Fotemustine | Sensitivity | true |