Annotation Detail
Information
- Associated Genes
- KIT
- Associated Variants
- KIT L576P
- Source Database
- MMMP
- Description
- In vitro testing showed that the cell viability of the L576P mutant cell line was not reduced by imatinib, nilotinib, or sorafenib small molecule KIT inhibitors
- MMMP Model
- 3
- MMMP State
- mut L576P (exon 11)
- MMMP Molecule
- KIT
- MMMP Molecule Alias
- c-KIT
- MMMP Modifier
- MMMP Modifier Alias
- MMMP Relationship
- resistance to
- MMMP Drug
- Nilotinib
- MMMP Reference
- Woodman SE, Mol Cancer Ther 2009, 8:2079-85
- MMMP DNA/mRNA/Protein
- DNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Nilotinib | Resitance or Non-Reponse | true |