Annotation Detail
Information
- Associated Genes
- MAP2K7
- Associated Variants
- MAP2K7 EXPRESSION
- Source Database
- MMMP
- Description
- RDEA119 is an allosteric MEK inhibitor. Melanoma cells (A375) were BRAF V600E mutated. Increasing levels of drug exposure correlated with increased inhibition of phosphorylated ERK (the MEK target). No formal MEK expression/chemosensitivity correlation was performed
- MMMP State
- expressed
- MMMP Molecule
- MEK
- MMMP Molecule Alias
- MEK1, MEK2
- MMMP Relationship
- sensitivity to
- MMMP Drug
- RDEA119
- MMMP Drug Alias
- BAY 869766
- MMMP Model
- 4
- MMMP Reference
- Iverson C, Cancer Res 2009, 69:6839-47
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| RDEA119 | Sensitivity | true |