Annotation Detail
Information
- Associated Genes
- BRAF
- Associated Variants
- BRAF V600E
- Source Database
- MMMP
- Description
- C-Raf siRNA knockdown results in decreased viability of YULAC (B-Raf(V600K)) and YUROB (B-Raf(WT)) melanoma cells, likely mediated by Bcl-2 inhibition rather than mitogen-activated protein kinase inhibition
- MMMP State
- mut V600E
- MMMP Molecule
- BRAF
- MMMP Molecule Alias
- B-Raf
- MMMP Relationship
- no relationship with
- MMMP Drug
- CRAF siRNA
- MMMP Model
- 3
- MMMP Reference
- Jilaveanu L, Clin Cancer Res 2009, 15:5704-13
- MMMP DNA/mRNA/Protein
- DNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| CRAF siRNA | Resitance or Non-Reponse | true |