Annotation Detail

Information
Associated Genes
STAT3
Associated Variants
STAT3 UNKNOWN
Source Database
MMMP
Description
The in vitro growth and DNA synthesis of five melanoma cell lines, whose STAT3 was activated (phosphorylated), was inhibited by TPA, whereas that of WM35 and WM39 cells, whose STAT3 activity was at negligible levels, was considerably slow and not affected by TPA
MMMP State
phosphorylated (activated)
MMMP Molecule
STAT3
MMMP Molecule Alias
Signal transducer and activator of transcription 3
MMMP Relationship
sensitivity to
MMMP Drug
TPA
MMMP Drug Alias
Tetradecanoyl phorbol acetate
MMMP Model
3
MMMP Reference
Oka M, J Biol Chem 2009, 284:30416-23
MMMP DNA/mRNA/Protein
protein
Drugs
Drug NameSensitivitySupported
TPASensitivitytrue