Annotation Detail

Information
Associated Genes
RAF1
Associated Variants
RAF1 EXPRESSION
Source Database
MMMP
Description
Melanoma cells expressing no ectopic C-Raf were more resistant to Sorafenib. Both oncogenic Ras and Sorafenib stabilize B-Raf(V600E)-C-Raf complexes, thereby impairing MAPK activation. This inhibitory function of C-Raf on B-Raf(V600E)-mediated MAPK activation may explain the lack of co-occurrence of B-Raf(V600E) and oncogenic Ras mutations
MMMP State
expressed
MMMP Molecule
CRAF
MMMP Molecule Alias
C-Raf
MMMP Relationship
sensitivity to
MMMP Drug
Sorafenib
MMMP Drug Alias
Nexavar (R)
MMMP Model
3
MMMP Reference
Karreth FA, Mol Cell 2009, 36:477-86
MMMP DNA/mRNA/Protein
protein
Drugs
Drug NameSensitivitySupported
SorafenibSensitivitytrue