Annotation Detail

Information
Associated Genes
BIRC3
Associated Variants
BIRC3 UNDEREXPRESSION
Source Database
MMMP
Description
Poly I:C is a toll like receptor 3 (TLR3) agonist. Sensitisation towards poly I:C-dependent caspase-8 activation and apoptosis in melanoma cells was also achieved by the synthetic Smac mimetic/inhibitor of apoptosis protein (IAP) antagonist, LBW242, or by specific downregulation of cIAP1 by siRNA
MMMP State
downregulated by
MMMP Molecule
IAP-1
MMMP Molecule Alias
Inhibitor of apoptosis protein 1
MMMP Modifier
IAP-1 siRNA
MMMP Relationship
sensitivity to
MMMP Drug
Poly(I:C)
MMMP Drug Alias
TLR3 agonist
MMMP Model
3
MMMP Reference
Weber A, Cell Death Differ 2010, 17:942-51
MMMP DNA/mRNA/Protein
mRNA
Drugs
Drug NameSensitivitySupported
Poly(I:C)Sensitivitytrue