Annotation Detail
Information
- Associated Genes
- ROS1
- Associated Variants
- ROS1 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- Oxymatrine (a natural quinolizidine alkaloid) dose-dependently increased the generation of reactive oxygen species in A375 cells, and N-acetylcysteine, a reactive oxygen species production inhibitor, almost completely blocked oxymatrine-induced apoptosis
- MMMP State
- downregulated by
- MMMP Molecule
- ROS
- MMMP Molecule Alias
- Reactive oxygen species
- MMMP Modifier
- N-acetylcysteine
- MMMP Modifier Alias
- NAC
- MMMP Relationship
- resistance to
- MMMP Drug
- Oxymatrine
- MMMP Model
- 3
- MMMP Reference
- Zhang Y, Anticancer Drugs 2010, Epub ahead of print
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Oxymatrine | Resitance or Non-Reponse | true |